ISF Council

The ISF takes its direction from a Council and Steering Committee chaired by Dr Derek Angus. This prestigious group of international experts in sepsis meet regularly to identify educational needs and develop synergistic programs and activities.

Dr Derek Angus – ISF Immediate Past Chair and Secretary

DerekAngusProfessor and Vice Chair of Research in the Department of Critical Care Medicine with secondary appointments in Medicine and Health Policy and Management, and Director of the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Laboratory at the University of Pittsburgh in Pittsburgh, Pennsylvania. He earned his medical degree and completed his residency training in Internal Medicine at the University of Glasgow in Glasgow, United Kingdom. Subsequently, he completed his Fellowship in Critical Care Medicine, combined with a Masters in Public Health degree at the University of Pittsburgh.

Dr Angus is a Fellow of the Royal College of Physicians and is a Fellow of the American College of Chest Physicians and the American College of Critical Care Medicine. He specializes in the epidemiologic, economic and health services research aspects of critical illness and ICU organization and delivery. He has studied the development and application of cost-effectiveness analysis in critical care, the capability and impact of alternative ICU organizational models, traditional and novel ICU risk prediction tools, and the incidence, cost and short- and long-term outcomes of critical illnesses such as sepsis and respiratory failure.

Dr Angus has attracted considerable research funding for these studies, authored or co-authored more than 350 publications, including more than 90 peer-reviewed articles, and lectured at scientific congresses nationally and internationally. Dr. Angus is currently leading three large NIH multicenter studies in the critically ill-GenIMS (Genetic and Inflammatory Markers of Sepsis), EA-PAC (Economic Analysis of the Pulmonary Artery Catheter), and ProNOx (Prolonged Outcomes in Neonatal Respiratory Failure after Nitric Oxide)

Dr Marc J.M Bonten

Marc BontenProfessor of Molecular Epidemiology of Infectious Diseases in the University Medical Center Utrecht (UMCU), Utrecht University, the Netherlands. He is Head of the department of Medical Microbiology and the research group Infectious Disease Epidemiology of the Julius Center for Health Sciences and Primary Care, both at the UMC Utrecht. Bonten is board certified in Clinical Microbiology.

His training included a research fellowship in Cook County Hospital in Chicago York (1995). Bonten is a former recipient of a VIDI stipend from the Dutch Science Organization. His research focuses on antibiotic resistance and infection prevention. He has published more than 350 original articles. Bonten has served as a member of Data Safety and Clinical Monitoring Boards of several pivotal phase III pneumonia trials, was (and is) coordinator of several international studies in ICU patients, the PI of the CAPiTA study (on pneumococcal vaccination in elderly) and the academic leader of the IMI-funded COMBACTE program (a
clinical trial network to evaluate new antibiotics for antibiotic resistant bacteria).

Dr. Thierry Calandra

CalandraProfessor of Medicine, Head, Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. He received his MD from the University of Lausanne and his PhD from the University of Utrecht, The Netherlands. He performed his internship and residency at the University Hospital in Lausanne and is board-certified in internal medicine and infectious diseases. His research training was accomplished at the Rockefeller University, New York, NY and at the Picower Institute for Medical Research, Manhasset, NY.

Dr Calandra is a member of many medical societies, including the Swiss Society for Infectious Diseases (President), the European Society of Clinical Microbiology and Infectious Diseases, the American Society for Microbiology and the Infectious Diseases Society of America. He is a member of the Research Council of the Swiss National Science Foundation. He is past President of the Fungal Infection Network of Switzerland, and Past-president of the International Immunocompromised Host Society and of the International Antimicrobial Therapy Group of the European Organisation for Research and Treatment of Cancer (EORTC).

Dr. R. Phillip Dellinger – Past ISF Chair

Phil DellingerProfessor of Medicine at Robert Wood Johnson Medical School, University of Medicine and Dentistry or New Jersey. He is Deputy Director for Education and Research for the Department of Medicine, Head, Division of Critical Care Medicine; Director, Medical/Surgical/Cardiovascular ICU; and Program Director of the Critical Care Medicine Fellowship training program at Cooper University Hospital, Camden, New Jersey. He is a fellow of the American College of Critical Care Medicine. He was previously the ACCP governor for both Texas and Missouri and gave the ACCP Roger C. Bone Honor lecture in 2001. Dr. Dellinger was president of the Society of Critical Care Medicine (SCCM) from 1998-1999. He is currently associate editor for the SCCM’s journal, Critical Care Medicine. He is the creator of the SCCM Fundamental Critical Care Support (FCCS) course now taught in 5 languages. Dr. Dellinger has authored over 300 journal articles, films and book chapters in the fields of critical care medicine and pulmonary disease, featuring both laboratory and clinical research. He has edited over a dozen books and journal issues with emphasis on sepsis and acute respiratory distress syndrome. He co-edits the annual publication of the Yearbook of Critical Care Medicine and co-edited the second and recently published third edition of the major critical care textbook, Critical Care Medicine (Mosby). He has received numerous awards and honors, to include induction into the Baylor College of Medicine Teaching Hall of Fame and the SCCM’s Distinguished Service Award.

Dr. Dellinger was an associate chair of the 1992 consensus conference that created the first definitions for sepsis and chaired the 1997 National Institutes of Health/American College of Chest Physicians workshop, “The Future of Sepsis Research”. He is past chairman of the International Sepsis Forum. He serves on the executive committee of the Surviving Sepsis Campaign (SSC). He co-chaired the committee that created the 2004 SSC International Guidelines on the Management of Severe Sepsis and Septic Shock and chaired the first revision in 2008. He previously served on the Institute for Healthcare Improvement ICU Collaborative Advisory Board and currently serves as faculty for both the New Jersey and Rhode Island Hospital Association ICU Performance Improvement Collaborative. He was the recipient of the Bronze Star and Purple Heart while serving in Vietnam.

Dr. Simon Finfer – ISF Chair

Senior Staff Specialist in Intensive Care at Royal North Shore Hospital in Sydney, Australia, a Professor in the Faculty of Medicine of the University of Sydney and at The George Institute for International Health in Sydney. He is a founding member and past-chair of the Australian and New Zealand Intensive Care Society Clinical Trial Group. His postgraduate qualifications include Fellowship of the Royal College of Physicians of the United Kingdom, Fellowship of the Royal College of Anaesthetics of the United Kingdom and Fellowship of the Joint Faculty of Intensive Care Medicine of the Royal Australasian College of Physicians and Australian and New Zealand College of Anaesthetists.

Professor Finfer’s major academic interest is the design and conduct of large scale randomized controlled trials in critical care. He was the lead investigator for the 6997 patient SAFE study (N Engl J Med 2004 May 27-350:247-56) and is the lead investigator and study Chair for the recently completed 6104 patient NICE-SUGAR study.

Dr. Flavia Machado

Flavia machadoProfessor of Intensive Care at the Federal University of São Paulo in São Paulo, Brazil. She is head of the Intensive Care Session of Anesthesiology, Pain and Intensive Care Department in this institution. Machado is board certified in internal medicine, infectious diseases and critical care. She received her MD from the Federal University of Minas Gerais (UFMG) and her residence training in internal medicine at the Medical Sciences University in Belo Horizonte, and also a Masters in Infectious Diseases. Subsequently, she completed her fellowship in Infectious Diseases as well as Critical Care training and a PHD degree at the University of São Paulo. Dr. Machado is presently the Vice President of the Latin America Sepsis Institute – LASI and its past-president. LASI is devoted to quality improvement process in Brazilian hospitals as well as to coordinate multicenter studies in sepsis field. She is part of the executive board of the Global Sepsis Alliance as well as the executive committee for the World Sepsis Day. She serves on the 2012 committee of the Surviving Sepsis Campaign International Guidelines. Dr. Machado is the editor-in-chief of “Revista Brasileira de Terapia Intensiva”, the official journal of the Brazilian Critical Care Association and the Portuguese Critical Care Association. Flavia is well published in the fields of sepsis and hemodinamics. Her research focuses primarily on improving the care and outcomes of critically ill patients with sepsis as well as on quality improvement process. She lectured at scientific congresses nationally and internationally and is also an author or co-author of numerous invited book chapters as well as editor of critical care books. She has received multiple grants from the Sao Paulo State Research Foundation. Dr Machado is a member of many medical societies, including the Brazilian Critical Care Society, the European Society of Critical Care Medicine and the Society of Critical Care Medicine.

Dr. John Marshall – Past ISF Chair

Professor of surgery at the University of Toronto and attending surgeon at the Toronto General Hospital, University Health Network. He is also a practicing intensivist who serves as Director of Research Inter-departmental Division of Critical Care Medicine, University of Toronto. He received his MD from the University of Toronto and his fellowship in general surgery at Dalhousie University. Subsequent to this, he pursued a fellowship in critical care and surgical immunobiology at McGill University.

He has authored more than 150 peer-reviewed papers and textbook chapters. He is formerly editor in chief of the journal Sepsis and serves on the editorial boards of Critical Care, Current Opinion in Critical Care, and Shock. He is a member of a number of professional societies in surgery, critical care medicine, and the basic science of inflammation. He is councilor of the Shock Society, and a member of the executive board of the Canadian Critical Care Trials Group.

Dr Marshall’s research interests include the basic and clinical biology of inflammation and the mechanisms of its resolution through programmed cell death, as well as the epidemiology and natural history of sepsis and the multiple organ dysfunction syndrome. He has been an active basic and clinical investigator in these areas and has lectured widely on inflammation and its role in the pathogenesis of the morbidity of critical illness.

Dr. Jean-Paul Mira

Received his medical degree from Reims Medical School in 1990 and since then has developed his career in medicine and research both in France and in the USA where he spent 3 years at the Scripps Research Institute in California.

His research interests are genetic predisposition to sepsis, cellular responses to micro-organisms, membrane dynamics, Toll-like Receptor signaling, functional genomics and sepsis-induced immune-suppression. Jean-Paul is well published in the fields of immunology and critical care.

Dr. Steven Opal – Past ISF Chair

Professor of Medicine at Brown Medical School, and the Director of the Infectious Disease Division at the Memorial Hospital of Rhode Island, Pawtucket, Rhode Island, USA.

He performed his internship and residency in internal medicine at Fitzsimmons Army Medical Center, Denver, CO and was a fellow in Infectious Diseases at the Walter Reed Army Medical Center, Washington, DC. He undertook tropical medicine training at the Armed Forces Institute of Pathology, Walter Reed Army Institute, in Washington DC.

Dr Opal is a member of many professional societies including the American Society for Microbiology, American Medical Association, Society for Critical care, International Immunocompromised Host Society, International Endotoxin Society, Infectious Disease Society of America, Shock Society, International Cytokine Society and the International Society of Infectious Diseases.

He serves on the editorial boards of Sepsis, Shock, Critical Care Medicine, Critical Care Forum and Advances in Sepsis.Dr Opal has also edited three text books- The Sepsis Text (along with J-L Vincent and J. Carlet), Endotoxin: Its Role in Health and Disease (along with S. Vogel, D. Morrison and H, Braude) and was the section editor for Special Problems in Infectious Disease Practice in Armstrong and Cohen’s Infectious Diseases, first and second editions.

He has served in many roles on various committees and research boards such as NIH Study Section for Microbiology and Mycology and General Clinical Research grant awards committee, the Medical Research Counsel (MRC) Review Section for Meningitis Research Foundation of the MRC, The British Society of Antimicrobial Chemotherapy as an external reviewer of research proposal for novel anti-inflammatory agents-Basic science division, and has been a medical writer of National Examinations.

Dr. Hallie Prescott – ISF Lowry Fink Fellow

Hallie C. Prescott is an Assistant Professor of Internal Medicine in the Division of Pulmonary and Critical Care Medicine at University of Michigan and a Core Investigator at the Ann Arbor VA Center for Clinical Management Research. Dr. Prescott received her undergraduate degree from Middlebury College, her medical degree from The Ohio State University, and a Master of Science in Healthcare Research from University of Michigan. She completed Internal Medicine Residency training at The Ohio State University, and Pulmonary/Critical Care Fellowship at University of Michigan.

Dr. Prescott’s research focuses on sepsis survivorship. She strives to understand how sepsis fits into a patient’s longitudinal physiologic and chronic disease trajectories, and to develop tools to reduce post-sepsis morbidity. Her research has been published in AJRCCM, JAMA, and BMJ. She has a career development award through the U.S. National Institutes of Health (General pathways and personalized risk of morbidity after sepsis) and an unrestricted critical care grant from the American Thoracic Society Foundation (Distinct subtypes of sepsis patients).

Dr. Tom van der Poll – Past ISF Chair

Professor of Medicine in the Academic Medical Center (AMC), University of Amsterdam, the Netherlands. He is Head of the Center of Experimental and Molecular Medicine and Chair of the Department of Infectious Diseases in this institution. In addition, he is Chair of the AMC Research Council and board member of the AMC Graduate School for Medical Sciences. Van der Poll is board certified in Internal Medicine and Infectious Diseases.

His training included a postdoctoral research fellowship in Cornell University Medical College in New York (1993-1995). Van der Poll is a former Fellow of the Royal Dutch Academy of Arts and Sciences (1995-2000). His research focuses on the innate immune and procoagulant response during sepsis. He has published more than 450 original articles and over 60 book chapters on this topic. Van der Poll has served as a member of Data Safety and Clinical Monitoring Boards of several pivotal phase III sepsis and pneumonia trials evaluating immunomodulatory agents.

Dr. Adrienne G. Randolph

Randolph_AdrienneDr. Randolph is Associate Professor of Anesthesia and Pediatrics at Harvard Medical School and a Senior Associate in Critical Care at Children’s Hospital, Boston, Massachusetts, USA.]

After receiving an MD from Stanford Medical School, she completed a Pediatrics residency and a Pediatric Critical Care Fellowship at the University of California at San Francisco (UCSF). While at UCSF, she completed research fellowships at the Institute for Health Policy Studies and at the Cardiovascular Research Institute. She subsequently received a Masters of Science in Biomedical Informatics from the University of Utah working with Dr. Alan Morris and colleagues on computer-based decision support to manage the mechanical ventilation of patients in the intensive care unit.

Dr. Randolph is the founder of the Pediatric Acute Lung Injury and Sepsis Investigator’s (PALISI) Network, a clinical research consortium of over 65 pediatric ICUs in the U.S. and Canada, and was Chair from 2002-2008. Dr. Randolph is a member of many professional societies including the Society for Critical Care Medicine, the American Academy of Pediatrics, and the American Thoracic Society.

Dr. Randolph has published extensively in the area of sepsis in children and co-authored the original definition of SIRS, sepsis and septic shock in children. With help from the ISF, she organized the First International Sepsis Forum on Sepsis in Infants and Children where many fundamental definitions of categories of infections were proposed. The proceedings of the symposium were published as a free online supplement to Pediatric Critical Care Medicine (http://journals.lww.com/pccmjournal/toc/2005/05001).   She has served on the pediatric subcommittee of the Surviving Sepsis Guidelines and has been the pediatric representative on the 2002 and 2001 U.S. national guidelines for the prevention of central venous catheter infections that are supported by multiple subspecialty and national organizations. She has received multiple grants from the U.S. National Institutes of Health and the Centers for Disease Control and Prevention to study life-threatening and fatal influenza infection in infants and children. In addition, she studies the role of vitamin D and vitamin D binding protein in innate immunity to infection in children.

Dr. Konrad Reinhart- ISF Past Chair

Reinhart_smallProfessor Reinhart is also the Interim Chairman of the Global Sepsis Alliance He is member of the Council of the World Federation on Societies of Intensive and Critical Care Medicine (WFSICCM).

In November 2002, Professor Reinhart became the Founding President of the German Sepsis Society and Speaker of the publicly funded Competency Network on Sepsis Research SepNet and is member of the Board of the Center for
Sepsis Control and Care (CSCC) in Jena.

He is extremely well published in the intensive care and sepsis areas. Prof Reinhart is an eminent clinical researcher and has been the principle investigator on several key sepsis trials.

Dr. Kathryn (Kathy) Rowan

Kathy RowanIn 1994, as a result of her DPhil (PhD) from the University of Oxford, Kathy established the Intensive Care National Audit & Research Centre (ICNARC) as an independent charitable (not-for-profit) organisation in the UK. ICNARC aims to promote improvements in the organisation and practice of critical care (both intensive and high dependency care) with a view to improving care and the outcomes and experiences of care for patients and for those who care for them (www.icnarc.org). ICNARC collaborates closely with many other local, regional, national and international organisations to help achieve this aim.

With respect to quality in critical care, ICNARC aims to contribute in three main areas: establishing quality; assessing quality; and improving quality. In establishing quality – the ICNARC Clinical Trials Unit, fully registered with the UK Clinical Research Collaboration, conducts a large and broad portfolio of research applying both quantitative and qualitative methods. In collaboration, ICNARC has won over £10 million in grants from a wide range of research funders. In assessing and improving quality, ICNARC has established and continues to develop two, major, national clinical audits both registered by the NHS Quality Accounts, one addressing adult critical care and one addressing in-hospital cardiac arrest. ICNARC promotes improvements in quality through routine comparative reporting at local, regional and national levels. In 2011, ICNARC released its first Annual Quality Report (2010-11 data) providing publicly identifiable results online (https://onlinereports.icnarc.org).

From 1994 to 2013, Kathy led and directed ICNARC and, in 2004, was awarded the Humphry Davy Medal by the UK Royal College of Anaesthetists as a mark of distinction for her significant contribution to critical care. In 2004/05, Kathy completed a Harkness Fellowship in Health Care Policy in the USA. Following appointment of a Chief Executive in 2014, Kathy now acts as ICNARC’s Director of Scientific & Strategic Development and remains Director of its Clinical Trials Unit. Kathy is also an Honorary Professor in the Department of Health Services Research and Policy at the London School of Hygiene & Tropical Medicine and in the Division of Research Strategy at University College London.

Dr. Mervyn Singer – ISF Treasurer and Chair Elect

SingerProfessor of Intensive Care Medicine at University College London, UK. His particular research focus is on (i) mechanisms of multi-organ failure, especially the roles of mitochondrial dysfunction and myocardial depression; (ii) mechanisms and management of septic shock; (iii) management of infection and infection control and (iv) monitoring of organ perfusion and perfusion adequacy. There is a strong translational emphasis to his studies that aim to travel from bench to bedside and back again. He has a healthily iconoclastic approach to current dogma; regardless of whether or not he will be proved right, it is nonetheless important to challenge the veracity of ingrained views and practices.

He has been heavily involved in multiple academic- and industry-instigated multi-centre trials, e.g. CORTICUS and PAC-Man. He sits on the Wellcome Trust Technology Transfer Panel and was appointed a UK NIHR (National Institute of Healthcare Research) Senior Investigator in 2009. His major sources of research funding comes from the UK Medical Research Council, the Wellcome Trust, NIHR and European Commission. He has co-written/edited several textbooks including the Oxford Handbook of Critical Care and the Oxford Textbook of Critical Care.

Dr. Charles Sprung

Dr Charles SprungDirector of the General Intensive Care Unit in the Department of Anesthesiology and Critical Care Medicine at Hadassah Hebrew University Medical Center where he has worked for the last 26 years. He was trained at the State University of New York- Downstate Medical Center in Internal Medicine and Critical Care Medicine. He was the Director of the Section of Critical Care Medicine in the Department of Medicine at the VA Medical Center and the University of Miami for 13 years. He graduated the University of Miami School of Law in 1988.

Professor Sprung was a council member of the Society of Critical Care Medicine (SCCM) from 1987 – 1994 and a council member of the European Society of Intensive Care Medicine (ESICM) from 1996-2010 and the Executive Committee from 2000-2010. He was the ESICM Treasurer from 2007-2010. He was the Chairman of the Committee on Ethics Section of the SCCM from 1987 to 1994 (and since that time has remained a member) and Chairman of the ESICM from 1996 to 2001 and again from 2004-2007 (he has remained a member of the Section for all these years).

Professor Sprung has been active in research particularly studying sepsis, septic shock and ethical issues for 35 years. He was a member of the ACCP/SCCM consensus conference on definitions of sepsis in 1991 and again in 2002. He has participated in many sepsis studies as an investigator, coordinator, clinical evaluation committee member or Safety and Efficacy Monitoring Committee member or chairman including those of encephalopathy and treatments with corticosteroids, monoclonal antibodies to endotoxin and tumor necrosis factor, interleukin-1 receptor antagonist, antithrombin III, tissue factor pathway inhibitor, human activated protein C and recombinant platelet-activating factor. His latest multicenter sepsis study “Corticosteroid therapy of septic shock- Corticus” was published in The New England Journal of Medicine (deleted several words in this sentence). He has been the Coordinator of several multi-center studies in ethics including End of Life Decision Making and Procedures in European Intensive Care Units – ETHICUS, Systematic Study of General Ethical Principles Involved in End of Life Decisions for Patients in European Intensive Care Units – ETHICATT and Triage Decision Making for the Elderly in European Intensive Care units – ELDICUS. He has published extensively in all of these areas and has more than 300 original articles and 50 books or book chapters.

Dr. Jean-Louis Vincent- Past ISF Chair

Dr Vincent is Professor of intensive care at University of Brussels, and a consultant intensivist in the Department of Intensive Care at the Erasme University Hospital in Brussels. He is President of the World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM) and a Past-President of the Belgian Society of Intensive Care Medicine (SIZ), the European Society of Intensive Care Medicine (ESICM), the European Shock Society (ESS), and the International Sepsis Forum (ISF). He is member of the Royal Medical Academy of Belgium.
Dr. Vincent has signed more than 850 original articles, some 400 book chapters and review articles, 930 original abstracts, and has edited 99 books. He is co-editor of the Textbook of Critical Care (Elsevier Saunders) and the “Encyclopedia of Intensive Care Medicine” (Springer). He is the editor-in-chief of “Critical Care”, “Current Opinion in Critical Care”, and “ICU Management” and member of the editorial boards of about 30 other journals.
He received several awards including the Distinguished Investigator Award of the Society of Critical Care Medicine, the College Medalist Award of the American College of Chest Physicians, the Society Medal (lifetime award) of the European Society of Intensive Care Medicine, the Laerdal Award and the prestigious Belgian scientific award of the FRS-FNRS (Prix Joseph Maisin-Sciences biomédicales cliniques).
His name appears about 1000 times in Pubmed, and has been cited more than 100,000 times, yielding an H-index above 130.